| Project | Rearrangements in genomes with unequal content |
|---|---|
| Date | 07/03/06 |
| Version | 1.0 |
| Purpose of Meeting | Finalize experiments |
| Supervisor present | Leong Hon Wai, Guillaume Bourque |
Run experiments to investigate the following:
Prof Leong commented that it would be better to use a common scale for all plots for a particular experiment.
At the moment, when merging two genomes G1 and G2, the gene content of the merged genome is taken to be the intersection of the content of G1 and G2. It may be possible retain more genes in the merged genome by considering a difference scheme of merging.
For example if G1 = [2,1,5,6] and G2 = [2,5,3,6] the merged genome Gm can be [2,1,5,3,6] since we can obtain information about the position of gene 1 and 3 from G1 and G2 respectively. However if G1 = [2,1,5,6] and G2 = [2,3,5,6] then it is not clear whether Gm should be [2,1,3,5,6] or [2,3,1,5,6].
Alternatively in the MGR-GT algorithm we are always solving the median problem for G1, G2 and G3. Suppose G1 = [2,1,5,6], G2 = [2,3,5,6] and G3 = [1,5,3,6,2] then we can let Gm = [2,1,3,5,6] where we include 1 and 3 in the median because it is present in 2 out of 3 genomes and the order of 1 and 3 in Gm can be determined by looking at their order in G3.