| Event | Honours Year Poster Presentation |
|---|---|
| Title | Rearrangements in genomes with unequal content |
| Presenter | Melvin Zhang, Honours year student, SOC. Supervisors: A/P Leong Hon Wai and Guillaume Borque, GIS |
| Date | 19th April 2006, 4 - 6pm at SOC1 level 5 TR 8 |
| Event | Presentation to SoC Computational Biology Lab |
|---|---|
| Title | Rearrangements in genomes with unequal content |
| Speaker | Melvin Zhang, Honours year student, SOC. Supervisors: A/P Leong Hon Wai and Guillaume Borque, GIS |
| Date | 6th April 2006, 3pm at S17 EC |
| Abstract | The phylogeny of a group of organisms is a tree representation of their evolutionary relationships. Phylogenetic analysis gives us insights into the evolution of traits within species as well as helps us understand the process of evolution. Most modern phylogenies are determined by comparing the DNA sequences of conserved genes but in recent years there has been a growing interest in the use of gene order rearrangements between genomes for phylogenetic reconstruction. Early programs, such as GRAPPA and MGR, which makes use gene order rearrangements, are limited to genomes with the same set of genes. We propose an extension of the MGR algorithm (Bourque and Pevzner, 2002) to handle genomes with different sets of genes. Experiments on simulated data showed that the accuracy of our extension with regards to the tree topology is a significant improvement over the naïve method of first removing the genes which are not common to all the genomes and then running the MGR program. |